Fosun Pharma’s Self-Developed Artemisinin Sequence Turn out to be Image of China’s Revolutionary Medicines

Collectively We Construct a Malaria-Free World

SHANGHAI, April 25, 2022 /PRNewswire/ — World Malaria Day on April 25, is an event that goals to advertise international malaria prevention and management. This yr, World Malaria Day is marked below the theme “Harness innovation to cut back the malaria illness burden and save lives.” Innovation has grow to be the key phrase within the struggle in opposition to malaria worldwide. As the primary Chinese language model pharmaceutical product nicely acknowledged in Africa, Artesun® (artesunate for injection), self-developed and manufactured by Fosun Pharma, has been used to deal with over 48 million extreme malaria sufferers worldwide by the top of 2021, which turned to be a logo of China’s self-developed revolutionary medicines to the world.

Within the Forties, China reported about 30 million malaria circumstances annualy^[1]. Since August 2016, China has not recorded a single indigenous malaria case, marking a major achievement within the struggle in opposition to malaria, which World Well being Group (WHO) hailed as “a notable feat^[1]“. On 30 June 2021, WHO introduced that China was formally licensed malaria-free.

The fiftieth anniversary of the invention of Artemisinin, a compound serving to save lives from malaria world wide

In line with WHO, in 2020, there have been an estimated 241 million circumstances of malaria worldwide and 627,000 malaria-related deaths in 85 nations. 96% of which occurred in Africa, with about 80% being kids below the age of 5^[2]. An African youngster dies of malaria each 55 seconds on common.

Malaria as soon as was a serious public well being downside in China. In its decades-long battle in opposition to malaria, China’s steady and exact prevention and management and its achievements in unbiased innovation and R&D of antimalarial medication have made outstanding contributions to the worldwide struggle in opposition to malaria.

On 23 Might 1967, the Collaborative Convention of Researchers on Drugs for Malaria Prevention and Remedy was held in Beijing. Mission 523 has been launched, which targeted on the identification of latest medicines for malaria prevention and therapy. In 1972, Tu Youyou and her group found Qinghaosu or artemisinin (the extracts from Artemisia annua L. / Qinghao) might successfully inhibit malaria parasites, which introduced the world a brand new chapter within the analysis of antimalarial medicines. Guilin Pharma, a subsidiary of Fosun Pharma joined Mission 523 to additional research and develop artemisinin derivatives. Artesunate was chemically synthesized on the premise of artemisinin by Guilin Pharma in 1977. One yr after, artesunate for injection was developed, which solved the issue of water solubility of artemisinin compounds.

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In 1987, Guilin Pharma was licensed the China No. X-01 Class I New Drug Certificates for artesunate by the Chinese language Ministry of Well being, and the No. X-02 New Drug Certificates for artesunate for injection. The worldwide use of artesunate within the therapy of malaria sufferers has helped to save lots of tens of millions of lives. Artesuante has been listed as one of many important antimalarial medicines by WHO since 2000.

To assist save extra lives from malaria, Fosun Pharma takes innovation as its core driver for sustainable progress and continues to enhance its merchandise’ high quality and improve its manufacturing administration requirements. On 21 December 2005, artesunate pill innovated by Fosun Pharma turned the primary pharmaceutical product prequalified by WHO, representing a zero breakthrough for the Chinese language pharmaceutical trade. On the finish of 2010, with the publication of a cowl web page article within the Lancet on the outcomes of a global scientific trial on Artesun® (artesunate for injection) from Fosun Pharma, Artesun® (artesunate for injection) was additionally granted WHO prequalification. In early 2011, WHO revised the Pointers for the Remedy of Malaria, altering the first-line therapy of extreme malaria from quinine to artesunate for injection.

Participation within the struggle in opposition to malaria in Africa with steady innovation in creating new medicines and measures for malaria prevention and therapy for youngsters

The struggle in opposition to malaria has at all times been a prime precedence of China’s medical and well being help to Africa. Since 2006, Fosun Pharma has actively participated within the Chinese language authorities’s China Support antimalaria challenge in Africa. The corporate additionally carried out numerous public welfare actions and worldwide malaria analysis cooperation to assist enhance the native malaria management capability in Africa. Fosun Pharma has been a core provider of antimalarial medicines to the World Fund, UNICEF, WHO, and nationwide drug procurement facilities in Africa.

From therapy to prevention, Fosun Pharma continues to offer extra prevention and therapy options for malaria sufferers, particularly kids. In August 2018, Fosun Pharma’s SPAQ-CO® Disp (co-packed sulfadoxine-pyrimethamine dispersible tablets and amodiaquine dispersible tablets), which indicated for the prevention of malaria in kids, was pre-qualified by WHO (WHO-PQ). By finish of 2021, round 175 million kids in excessive malaria transmission African nations had benefited from the “Seasonal Malaria Chemoprevention Program”, for which SPAQ-CO® Disp is used because the core drug. SMC with SPAQ-CO® Disp successfully diminished the morbidity of malaria in kids below 5 years previous in Africa.

Fosun Pharma’s antimalarial product portfolio covers malaria prevention, and coverings of difficult and extreme malaria. As of January 2022, Fosun Pharma has 30 antimalarial merchandise prequalified by WHO, together with 26 completed dosage varieties and 4 APIs, making Fosun Pharma the main antimalarial drug producer with essentially the most certifications.

After greater than 15 years of operation in Africa, Fosun Pharma has established a gross sales and advertising community in 39 nations and areas in Africa, making certain the continued availability of drugs and healthcare merchandise similar to antimalarial medicines in Africa.

Since 2020, the COVID-19 pandemic has unfold worldwide, which introduced essential challenges to the worldwide malaria responses. In line with the World Malaria Report 2021 launched by the WHO, roughly two-thirds of the extra deaths (47,000) in 2020 had been linked to disruptions within the provision of malaria prevention, analysis and therapy through the COVID-19 pandemic^[3].

As a world innovation-driven pharmaceutical and healthcare trade group deep-rooted in China, Fosun Pharma has actively responded to the decision of the WHO. Whereas striving to make sure the antimalarial drug provide to the worldwide market, Fosun Pharma has accelerated the technological innovation of COVID-19 merchandise to safe the availability of related supplies and strategic merchandise., in order to constantly contribute to the prevention and management of the pandemic.

“Malaria is a world public well being situation that draws in depth concern,” mentioned Wu Yifang, Chairman and CEO of Fosun Pharma. “We at all times adhere to revolutionary R&D and uphold the mission of serving to the world eradicate malaria as our company social accountability. Fosun Pharma’s international operational networks will additional enhance the supply and affordability of antimalarial medicines and different medical merchandise in Africa. As well as, we try to contribute to the achievement of the World Technical Technique for Malaria 2016-2030 proposed by WHO to manage and eradicate malaria.”

About Fosun Pharma

Based in 1994, Shanghai Fosun Pharmaceutical (Group) Co., Ltd. (“Fosun Pharma”; inventory code: 600196. SH, 02196. HK) is a world innovation-driven pharmaceutical and healthcare trade group deep-rooted in China. Fosun Pharma straight operates companies together with pharmaceutical manufacturing, medical units, medical analysis, and healthcare providers. As a shareholder of Sinopharm Co., Ltd., Fosun Pharma expands its areas within the pharmaceutical distribution and retail enterprise.

Fosun Pharma is patient-centered and scientific needs-oriented. The corporate enriches its revolutionary product pipeline via diversified and multi-level cooperation fashions similar to unbiased analysis and growth, cooperative growth, license-in, and in-depth incubation. Fosun Pharma has shaped technological platforms for revolutionary small molecule medication, antibody medication, and cell remedy with a deal with key illness areas together with oncology and immunomodulation, metabolism and digestive system, and central nervous system. Fosun Pharma additionally vigorously explores cutting-edge applied sciences, similar to RNA, oncolytic viruses, gene remedy and PROTAC, to boost its innovation capabilities.

Guided by the 4IN technique (Innovation, Internationalization, Integration, and Intelligentization), Fosun Pharma will uphold the event mannequin of “innovation transformation, built-in operation, and regular progress”, with the mission of making shareholder values in addition to selling the worldwide networks via strengthening its revolutionary R&D and in-licensing skill and enriching its product pipelines. Fosun Pharma will actively promote the digital and bodily enterprise format within the pharmaceutical and healthcare trade and is dedicated to turning into a first-class enterprise within the international mainstream medical and well being market.

For extra info, please go to our official web site: www.fosunpharma.com.

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SOURCE Fosun Pharma